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Over time, patients may experience a turning in of the knees, known as valgus deformity, and advanced arthritis that eventually requires joint replacement surgery

Anthracyclines have a complex mechanism of action including inhibition of enzymes such as topoisomerase II, resulting in DNA double-strand breaks, intercalation into DNA and also generation of reactive oxygen species

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p 1.5 mg/week

Medical supervision with personalized dosage and lifestyle guidance maximizes safety and efficacy