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However, like other Khavinson peptides , Pinealon faces skepticism - most research conducted in Russia with limited Western replication, no FDA approval or large-scale international trials, mechanisms not fully elucidated despite decades of study, optimal dosing based on Russian protocols without rigorous dose-finding studies, and long-term safety data from clinical use rather than controlled trials

2022 research published in the Indian Journal of Dermatology also suggests that sun protection can help reverse mild hyperpigmentation spots, including those caused by melasma