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CI, confidence interval, BMI, body mass index

339 Additionally, PFKFB3-driven glycolysis also promotes histone Kla and boosts profibrotic gene expression in silica-treated mice, a process that can be inhibited by activating glucagon-like peptide-1 receptor (GLP-1R), disrupting the interaction between the NLRP3 inflammasome and PFKFB3, and intensifying pulmonary fibrosis progression

A recent meta-analysis involving 32,884 patients from 19 randomized controlled trials further confirmed a 23% reduction in all-cause mortality associated with GLP-1RAs use (OR = 0.77) (Rivera et al., 2024)

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Further studies are required to assess the efficacy and elucidate the underlying mechanisms of MSC-combined cellular therapy