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This review uses public information from the company's website and industry sources

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Patients were randomly assigned to orforglipron (12 mg or 36 mg) or semaglutide (7 mg or 14 mg) with a treatment period of 52 weeks, from 22 September 2022 to 22 August 2025, and drugs were administered orally once per day

The evaluation of retatrutide results from recent clinical trials provides a critical lens through which we, as a scientific community, assess its potential impact on weight management