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GLP-1RAs promote weight loss by reducing appetite via slowed gastric emptying and acting on the brains appetite centres

In the HFD/STZ-induced SD rat model, the San-Huang-Yi-Shen Capsule (SHYS) promotes PINK1/Parkin-mediated mitophagy, inhibits the activation of the NLRP3 signaling pathway, attenuates mitochondrial damage, and reduces inflammatory responses, which results in the improvement of DKD [133]