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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

Bridgewater, NJ: Sanofi-aventis U.S., LLC.;2019

Although patients receiving exenatide IR and experiencing longer durations of nausea and vomiting tended to lose more weight, those in the trial group who did not experience the gastrointestinal symptoms (70%) generally lost weight as well (166, 224)

GLP-1R/GDF15 co-agonists largely preclinical pair GLP-1R activation with GFRAL-mediated hindbrain signaling, an appetite-suppressive pathway that is mechanistically non-overlapping with the GLP-1R satiety circuit