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Induction of Sulfiredoxinviaan Nrf2-Dependent pathway and hyperoxidation of Peroxiredoxin III in the lungs of mice exposed to hyperoxia

excessive intake of specific agents, such as vitamin E, has been linked to adverse outcomes in human clinical trials, including an elevated risk of hemorrhagic stroke and all-cause mortality [218, 219]

Interestingly, male patients with inflammatory bowel disease (IBD) exhibit downregulated GPER expression in intestinal tissue, accompanied by elevated proinflammatory cytokine levels, whereas female patients are more likely to benefit from GPER agonists, which increase anti-inflammatory signaling and reduce intestinal inflammation [76]

Toxicity mechanisms of nanoparticles in the male reproductive system

Kudahl, K., Fisker, S