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Amylin lowers postprandial glucose through three combined actions: slowing gastric emptying, suppressing inappropriate postprandial glucagon (which reduces liver glucose output), and reducing food intake

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The paper made its way through peer review and even attracted a positive Editorial comment, describing the findings as "striking" and recommending that practitioners should "not hesitate to prescribe the medications when an indication exists" This is the kind of work that can lead to unwarranted patient demand for medication

Adults 18 and older on Medicare Part D who meet one of three BMI tiers at the time GLP-1 therapy is initiated: BMI 35, BMI 30 with a comorbidity (heart failure with preserved EF, uncontrolled hypertension despite two antihypertensives, or chronic kidney disease stage 3a+), or BMI 27 with a cardiovascular comorbidity (pre-diabetes by ADA criteria, prior heart attack, prior stroke, or symptomatic peripheral artery disease)

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