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This article profiles these trials and their implications for management of CVD in people with obesity after briefly tracing the path to the launch of these studies

Long-term success depends on developing healthier lifestyle habits along with medication therapy

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2019 Nov 28;381(22):2103-2113

This is partly due to reduced food intake and partly due to increased metabolic effects from the higher dose

As mentioned, along with GLP-1RAs, evidence has been gathered for the cardiovascular protective actions of SGLT2i, with the latter conferring a more pronounced protection with respect to HF and CKD, whereas GLP-1RAs may be associated with a greater benefit in relation to fatal and non-fatal stroke [82]