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This is why some clinicians, including Paloma health care providers who prescribe GLP-1 drugs, monitor thyroid function more closely after initiating a GLP-1

Patients should continue their biologic or oral agent while we monitor how their skin and systemic health respond over several months

The serendipitous discovery of exendin-4 led to the development of exenatide immediate-release (exenatide IR, Byetta), a synthetic version of exendin-4 with C-terminal amidation to enhance its stability [ Figure 2 , Table 1 ], which became the first FDA-approved GLP-1RA in 2005 for the treatment of T2DM in adults [ Table 2 ]

Because remember when our sex hormones shift they negatively they throw off our digestive system

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In a prospective cohort study of 36 patients with albuminuria who were initiated on sitagliptin 50 mg daily, patients experienced a significant change in both systolic and diastolic BP that was apparent after 6 months (baseline systolic BP 140 +/ 18 mmHg dropped to 129 +/ 17 mmHg and baseline diastolic BP 77 +/ 10 mmHg fell to 73 +/ 7 mmHg