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Alk-RSL3, an alkynylated RSL3 derivative, is also senolytic (Fig

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Importantly, the Y390-containing loop again pivoted away from C326, similar to the UNC10088 C -dependent structure, yet Y390 did not appear to be making any specific contacts with the benzaldehyde of UNC10415667 C

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The newer Foundayo (orforglipron), FDA approved April 2026, is the first oral GLP-1 with no food or water restrictions although average weight loss is lower than the injectables (11% vs 15-20%)